The latest versions of several popular NES emulators do not support edited versions of certain Konami games, including Ganbare Goemon Gaiden 2. The title screen will display incorrectly, and the game will most likely crash shortly thereafter, rendering it unplayable.

I can't fix that by editing the ROM, as the cause of the issue is within the source code for those emulators. However, there are still many available methods of playing the patched game with no issues, including:

Windows
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FCEUX (2.1.4a and below)
Nestopia (1.37 and below)
FCEU-mm ("final" v0.98.13mm) <i>(This is a fork of FCEU from before FCEUX incorporated the change)
Mednafen with MedGui v1.99999 <i>(This is based on an older version of FCEUX, so future updates might break compatibility)
Mesen (v0.9.5)
Nintendulator ("unstable" v0.9.7.5)
VirtuaNES (v0.97)


Android
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"Free NES Emulator" by Deimos Applications (v2.15)


RetroPie
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lr-fceumm


NES Mini
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Hakchi2 CE v1.2.4 with RetroArch Neo 1.7.0